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Angiopoietin-2, its soluble receptor Tie-2 and subclinical cardiovascular disease in a population-based sample.
- Source :
-
Heart (British Cardiac Society) [Heart] 2015 Feb; Vol. 101 (3), pp. 178-84. Date of Electronic Publication: 2014 Oct 06. - Publication Year :
- 2015
-
Abstract
- Objective: Higher circulating Angiopoietin-2 (Ang-2) levels predict cardiovascular events and mortality in clinical samples and in the general population. To better understand the underlying mechanisms, we investigated the association of circulating Ang-2 and sTie-2 (the soluble form of the Ang-2 receptor) levels with various measures of subclinical cardiovascular disease.<br />Methods: Cross-sectional data of 3204 participants (1654 women) aged 25-88 years from the population-based Study of Health in Pomerania were analysed. LV mass (LVM) and fractional shortening were determined echocardiographically as indices of cardiac structure and function, respectively. Intima media thickness (IMT) of the common carotid artery, the number of carotid plaques and flow-mediated dilation (FMD) were used to characterise large and medium-sized arterial structure and function.<br />Results: Multivariable-adjusted linear and negative binomial regression models revealed an inverse association of circulating Ang-2 levels (independent variable) with fractional shortening (ß=-0.51 per 1 SD increment; 95% CI -0.86 to -0.16, p=0.005) and a positive association with number of carotid plaques (rate ratio=1.04 95% CI 1.01 to 1.07, p=0.019). No associations of Ang-2 or sTie-2 with LVM, IMT and FMD were found.<br />Conclusions: Circulating Ang-2 levels were associated with select subclinical cardiovascular disease traits, consistent with the notion that the Ang-2-pathway plays a role in mediating cardiovascular morbidity.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers blood
Cardiovascular Diseases diagnosis
Cardiovascular Diseases epidemiology
Carotid Intima-Media Thickness
Cross-Sectional Studies
Disease Progression
Echocardiography
Female
Follow-Up Studies
Germany epidemiology
Humans
Incidence
Male
Middle Aged
Retrospective Studies
Risk Factors
Survival Rate trends
Angiopoietin-2 blood
Cardiovascular Diseases blood
Population Surveillance
Receptor, TIE-2 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1468-201X
- Volume :
- 101
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Heart (British Cardiac Society)
- Publication Type :
- Academic Journal
- Accession number :
- 25286927
- Full Text :
- https://doi.org/10.1136/heartjnl-2014-306056