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Methylphenidate treatment affects mitogen-activated protein kinase activation in the striatum of young rats.

Authors :
Comim CM
Pereira JG
Ribeiro SJ
Quevedo J
Boeck CR
Source :
Acta neuropsychiatrica [Acta Neuropsychiatr] 2013 Aug; Vol. 25 (4), pp. 235-9.
Publication Year :
2013

Abstract

Objective: Methylphenidate (MPD) is a drug prescribed for the treatment of attention deficit/hyperactivity disorder and its therapeutic effect is attributed to the inhibition of dopamine.<br />Methods: Young male Wistar rats were administered MPD (1, 2, 5, or 10 mg/kg) once a day or an intraperitoneal injection of saline for 28 days (chronic treatment) or for 1 day (acute treatment). Two hours after the last administration the animals were decapitated and their striatum was dissected.<br />Results: In this work, we show that continued treatment with MPD is capable of modifying the levels of phosphorylation of proteins JNK1/2 (c-Jun amino-terminal kinases 1 and 2) and ERK1/2 (extracellular signal-regulated kinases 1 and 2). Whereas the level of phosphorylation of protein ERK increased significantly, that of proteins JNK1/2 diminished.<br />Conclusion: The alteration in the level of activation of mitogen-activated protein kinases can be a molecular mechanism through which MPD exerts its therapeutic effect.

Details

Language :
English
ISSN :
1601-5215
Volume :
25
Issue :
4
Database :
MEDLINE
Journal :
Acta neuropsychiatrica
Publication Type :
Academic Journal
Accession number :
25287637
Full Text :
https://doi.org/10.1111/acn.12015