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Targeted sequencing using a 47 gene multiple myeloma mutation panel (M(3) P) in -17p high risk disease.
- Source :
-
British journal of haematology [Br J Haematol] 2015 Feb; Vol. 168 (4), pp. 507-10. Date of Electronic Publication: 2014 Oct 10. - Publication Year :
- 2015
-
Abstract
- We constructed a multiple myeloma (MM)-specific gene panel for targeted sequencing and investigated 72 untreated high-risk (del17p) MM patients. Mutations were identified in 78% of the patients. While the majority of studied genes were mutated at similar frequency to published literature, the prevalence of TP53 mutation was increased (28%) and no mutations were found in FAM46C. This study provides a comprehensive insight into the mutational landscape of del17p high-risk MM. Additionally, our work demonstrates the practical use of a customized sequencing panel, as an easy, cheap and fast approach to characterize the mutational profile of MM.<br /> (© 2014 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 168
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 25302557
- Full Text :
- https://doi.org/10.1111/bjh.13171