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Genetics of sudden cardiac death in the young.
- Source :
-
Clinical genetics [Clin Genet] 2015 Aug; Vol. 88 (2), pp. 101-13. Date of Electronic Publication: 2014 Nov 22. - Publication Year :
- 2015
-
Abstract
- Sudden cardiac death (SCD) has an enormous impact on those who are left behind, evoking strong feelings of anxiety and incomprehension because such a dramatic event was not anticipated. Moreover, over the last decade a prominent genetic contribution to the pathogenesis of SCD has been unveiled. As many inherited cardiac diseases show an autosomal dominant pattern of inheritance, the risk of carrying the same inherited predisposition is a real concern for the relatives. In this article, we discuss the major causes of primary electrical disorders, cardiomyopathies and thoracic aortic dissection and address issues in genotype-phenotype correlation, personalized management and cardiogenetic counselling.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1399-0004
- Volume :
- 88
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 25307320
- Full Text :
- https://doi.org/10.1111/cge.12519