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High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma.
- Source :
-
Scientific reports [Sci Rep] 2014 Oct 15; Vol. 4, pp. 6625. Date of Electronic Publication: 2014 Oct 15. - Publication Year :
- 2014
-
Abstract
- Melanoma-associated antigens (MAGE)-A9 has been reported to play important roles in the development of human cancers. However, the association between MAGE-A9 expression and the clinicopathological characteristics of hepatocellular carcinoma (HCC) is not well understood. The study was to detect the expression of MAGE-A9 in human HCC and investigate the association between its expression and the clinicopathological characteristics of HCC. Reverse transcription-polymerase chain reaction (RT-PCR), one-step quantitative -PCR (qPCR) and immunohistochemistry (IHC) analyses were performed to characterize the expression of MAGE-A9 in HCC cell lines and tissues. Kaplan-Meier survival and Cox regression analyses were employed to evaluate the prognosis of 100 HCC patients. The results showed that the expression of MAGE-A9 in HCC was significantly higher than that in non-cancerous cells and tissues. Moreover, the expression level of the MAGE-A9 protein in HCC was related to the pathological grade (p = 0.003), portal vein invasion (p = 0.001), distant metastasis (p = 0.022) and TNM stage (p = 0.005). Cox regression analysis further revealed that MAGE-A9 expression is an independent prognostic factor for disease-free survival (p = 0.006) and overall survival (p = 0.022). These data are the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for HCC and that high MAGE-A9 expression suggests unfavorable survival outcomes in HCC patients.
- Subjects :
- Adult
Antigens, Neoplasm genetics
Carcinoma, Hepatocellular pathology
Female
Gene Expression Regulation, Neoplastic
Hep G2 Cells
Humans
Kaplan-Meier Estimate
Liver Neoplasms pathology
Male
Middle Aged
Neoplasm Proteins genetics
Antigens, Neoplasm biosynthesis
Carcinoma, Hepatocellular genetics
Liver Neoplasms genetics
Neoplasm Proteins biosynthesis
Prognosis
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 4
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 25315972
- Full Text :
- https://doi.org/10.1038/srep06625