Back to Search
Start Over
The ratio of the estradiol metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16-OHE1) may predict breast cancer risk in postmenopausal but not in premenopausal women: two case-control studies.
- Source :
-
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2015 May; Vol. 291 (5), pp. 1141-6. Date of Electronic Publication: 2014 Oct 16. - Publication Year :
- 2015
-
Abstract
- Purpose: Two main estradiol metabolites have different biological behavior with tumorigenic features of 16-OHE1 and antiproliferative characteristics of 2-OHE1. We investigated the ratio of these estradiol metabolites in pre- and postmenopausal patients with breast cancer (BC) within two case-control studies.<br />Methods: From 41 premenopausal patients with (cases) and without (controls N = 211) BC and 207 postmenopausal patients with and without BC (N = 206), urine samples were collected. Urine samples were collected prior to surgery and stored at -20 °C until measurement by ELISA. The multiple linear regression test with two interactions was performed to evaluate the influence of different factors on the metabolic ratio.<br />Results: In premenopausal patients, log ratio of 2-OHE1/16-OHE1 was 0.25 (CI 0.20;0.29) and 0.21 (CI 0.11;0.31) for controls and cases without significant difference. In postmenopausal patients, log ratio was 0.22 (CI 0.17;0.26) and 0.11 (CI 0.07;0.15) in controls and cases, respectively, and was statistically significantly lower (p = 0.0002). Log ratio was significantly influenced by BMI, but only in postmenopausal patients, an increased BMI resulted in a significantly (p < 0.042) decreased ratio.<br />Conclusions: Our case control studies suggest that in postmenopausal women a different metabolism of estrogens may play a role in the tumorigenesis of breast cancer. This genetically determined metabolism could be influenced by the exogenic factor BMI. In premenopausal women different hormone levels at different time points of the menstrual cycle may be an explanation that why we could not find an influence of estrogen metabolism.
- Subjects :
- Adult
Biomarkers urine
Breast Neoplasms genetics
Case-Control Studies
Enzyme-Linked Immunosorbent Assay methods
Estradiol metabolism
Estrogens metabolism
Female
Genetic Predisposition to Disease
Humans
Middle Aged
Postmenopause urine
Premenopause urine
Sensitivity and Specificity
Breast Neoplasms urine
Estradiol urine
Hydroxyestrones urine
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0711
- Volume :
- 291
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of gynecology and obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 25318606
- Full Text :
- https://doi.org/10.1007/s00404-014-3512-1