Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.

Authors :: Berrios C
Jung J
Primi B
Wang M
Pedamallu C
Duke F
Marcelus C
Cheng J
Garcea RL
Meyerson M
DeCaprio JA
Source :: Journal of virology [J Virol] 2015 Jan; Vol. 89 (1), pp. 857-62. Date of Electronic Publication: 2014 Oct 15.
Publication Year :: 2015
Abstract: Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

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