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Unique expression pattern of viral proteins in human herpesvirus 8-positive plasmablastic lymphoma: a case report.
- Source :
-
International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2014 Aug 15; Vol. 7 (9), pp. 6415-8. Date of Electronic Publication: 2014 Aug 15 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Background: Human herpesvirus 8 (HHV8)-positive plasmablastic lymphoma is a disease which correlates with acquired immunodeficiency syndrome (AIDS). Little is known about the pathogenesis of the disease due to its rarity. We report an autopsy case about AIDS related HHV-8-positive plasmablastic lymphoma and presents an examination about HHV8 related proteins for the disease by using immunohistochemical techniques.<br />Case Presentation: Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi's sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1.<br />Conclusion: These findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.
- Subjects :
- Antigens, Viral analysis
Autopsy
Basic-Leucine Zipper Transcription Factors analysis
Biomarkers, Tumor analysis
Castleman Disease immunology
Castleman Disease pathology
Cell Proliferation
Fatal Outcome
Herpesvirus 8, Human immunology
Herpesvirus 8, Human pathogenicity
Host-Pathogen Interactions
Humans
Immediate-Early Proteins analysis
Immunohistochemistry
Lymphoma, AIDS-Related immunology
Lymphoma, AIDS-Related pathology
Male
Middle Aged
Nuclear Proteins analysis
Repressor Proteins analysis
Sarcoma, Kaposi immunology
Sarcoma, Kaposi pathology
Trans-Activators analysis
Ureteral Neoplasms immunology
Ureteral Neoplasms pathology
Virus Replication
Castleman Disease virology
Lymphoma, AIDS-Related virology
Sarcoma, Kaposi virology
Ureteral Neoplasms virology
Viral Proteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2625
- Volume :
- 7
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of clinical and experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25337302