Plasma exchanges and immunosuppression for anti-complement factor H associated hemolytic uremic syndrome.

Background: Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure.
Case Characteristics: 7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies.
Intervention: Prompt initiation of plasma exchanges and immunosuppression.
Outcome: Remission of hematological and kidney functions.
Message: Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.