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Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice.
- Source :
-
Malaria journal [Malar J] 2014 Nov 05; Vol. 13, pp. 426. Date of Electronic Publication: 2014 Nov 05. - Publication Year :
- 2014
-
Abstract
- Background: The design and development of an effective malaria vaccine against the pre-erythrocytic and erythrocytic-stages of infection present a great challenge.<br />Methods: In the present study, protective efficacy of oligomannose-coated liposome (OML)-entrapped merozoite and sporozoite antigens against Plasmodium berghei challenge infection in BALB/c mice was evaluated.<br />Results: Subcutaneous immunization with truncated merozoite surface protein 1 entrapped with OML (OML-PbMSP1) prolonged survival, but failed to protect the mice from erythrocytic-stage infection, despite the antigen-specific antibody responses induced by the immunization regimen. In contrast, immunization with circumsporozoite protein entrapped with OML (OML-PbCSP) elicited antigen-specific humoral and cellular responses, which correlated with substantial protection against sporozoite challenge infections.<br />Conclusions: The current results represent the use of an oligomannose-coated liposome-based vaccine against pre-erythrocytic and erythrocytic stages malaria infection. This approach may offer a new vaccination strategy against malaria infection.
- Subjects :
- Animals
Disease Models, Animal
Female
Injections, Subcutaneous
Malaria immunology
Malaria Vaccines administration & dosage
Mannose
Merozoite Surface Protein 1 immunology
Mice
Mice, Inbred BALB C
Liposomes immunology
Malaria prevention & control
Malaria Vaccines immunology
Plasmodium berghei immunology
Protozoan Proteins immunology
Sporozoites immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2875
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Malaria journal
- Publication Type :
- Academic Journal
- Accession number :
- 25373617
- Full Text :
- https://doi.org/10.1186/1475-2875-13-426