Back to Search
Start Over
Distinct modes of transmission of tuberculosis in aboriginal and non-aboriginal populations in Taiwan.
- Source :
-
PloS one [PLoS One] 2014 Nov 13; Vol. 9 (11), pp. e112633. Date of Electronic Publication: 2014 Nov 13 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Tuberculosis incidence among aborigines is significantly higher than for Han Chinese in Taiwan, but the extent to which Mycobacterium tuberculosis (MTB) strain characteristics contribute to this difference is not well understood. MTB isolates from aborigines and Han Chinese living in eastern and southern Taiwan, the major regions of aborigines, were analyzed by spoligotyping and 24-loci MIRU-VNTR. In eastern Taiwan, 60% of aboriginal patients were ≤20 years old, significantly younger than the non-aboriginal patients there; aborigines were more likely to have clustered MTB isolates than Han Chinese (odds ratio (OR) = 5.98, p<0.0001). MTB lineages with high clustering were EAI (54.9%) among southern people, and Beijing (62.5%) and Haarlem (52.9%) among eastern aborigines. Resistance to first-line drugs and multidrug resistance (MDR) were significantly higher among eastern aborigines (≥15%) than in any other geographic and ethnic group (p<0.05); MDR was detected in 5 of 28 eastern aboriginal patients ≤20 years old. Among patients from the eastern region, clustered strains (p = 0.01) and aboriginal ethnicity (p = 0.04) were independent risk factors for MDR. The lifestyles of aborigines in eastern Taiwan may explain why the percentage of infected aborigines is much higher than for their Han Chinese counterparts. The significantly higher percentage of the MDR-MTB strains in the aboriginal population warrants close attention to control policy and vaccination strategy.
- Subjects :
- Adolescent
Adult
Aged
Antitubercular Agents therapeutic use
Asian People
Drug Resistance, Multiple, Bacterial genetics
Ethnicity
Female
Genotype
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Minisatellite Repeats
Multilocus Sequence Typing
Mycobacterium tuberculosis classification
Mycobacterium tuberculosis drug effects
Taiwan epidemiology
Tuberculosis, Pulmonary drug therapy
Tuberculosis, Pulmonary epidemiology
Genome, Bacterial
Mycobacterium tuberculosis genetics
Tuberculosis, Pulmonary ethnology
Tuberculosis, Pulmonary transmission
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25393403
- Full Text :
- https://doi.org/10.1371/journal.pone.0112633