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Effect of omega-3 fatty acid ethyl esters on the oxylipin composition of lipoproteins in hypertriglyceridemic, statin-treated subjects.
- Source :
-
PloS one [PLoS One] 2014 Nov 13; Vol. 9 (11), pp. e111471. Date of Electronic Publication: 2014 Nov 13 (Print Publication: 2014). - Publication Year :
- 2014
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Abstract
- Background: Oxylipins mediate inflammation, vascular tension, and more. Their presence in lipoproteins could explain why lipoproteins mediate nearly identical activities.<br />Methods: To determine how oxylipins are distributed in the lipoproteins of hypertriglyceridemic subjects, and whether omega-3 fatty acids alter them in a manner consistent with improved cardiovascular health, we recruited 15 dyslipidemic subjects whose levels of low density lipoprotein cholesterol (LDL-C) were at goal but who remained hypertriglyceridemic (200-499 mg/dL). They were treated them with the indicated dose of 4 g/d omega-3 acid ethyl esters (P-OM3) for 8 weeks. Measured oxylipins included mid-chain alcohols (HETEs, HEPEs and HDoHEs), ketones (KETEs), epoxides (as EpETrEs, EpETEs, and EpDPEs).<br />Results: At baseline, arachidonate-oxylipins (HETEs, KETEs, and EpETrEs) were most abundant in plasma with the greatest fraction of total abundance (mean |95% CI|) being carried in high density lipoproteins (HDL); 42% |31, 57| followed by very low density lipoproteins (VLDL); 27% |20, 36|; and LDL 21% |16, 28|. EPA- and DHA-derived oxylipins constituted less than 11% of total. HDL carried alcohols and epoxides but VLDL was also rich in ketones. Treatment decreased AA-derived oxylipins across lipoprotein classes (-23% |-33, -12|, p = 0.0003), and expanded EPA-(322% |241, 422|, p<0.0001) and DHA-derived oxylipins (123% |80, 176|, p<0.0001).<br />Conclusions: Each lipoprotein class carries a unique oxylipin complement. P-OM3 treatment alters the oxylipin content of all classes, reducing pro-inflammatory and increasing anti-inflammatory species, consistent with the improved inflammatory and vascular status associated with the treatment.<br />Trial Registration: ClinicalTrials.gov NCT00959842.
- Subjects :
- Arachidonic Acid blood
Epoxy Compounds blood
Female
Humans
Hypertriglyceridemia blood
Hypertriglyceridemia drug therapy
Ketones blood
Lipoproteins metabolism
Lipoproteins, HDL blood
Lipoproteins, LDL blood
Lipoproteins, VLDL blood
Male
Middle Aged
Oxylipins metabolism
Fatty Acids, Omega-3 therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hypolipidemic Agents therapeutic use
Lipoproteins blood
Oxylipins blood
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25393536
- Full Text :
- https://doi.org/10.1371/journal.pone.0111471