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Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.
- Source :
-
Diabetologia [Diabetologia] 2015 Feb; Vol. 58 (2), pp. 290-4. Date of Electronic Publication: 2014 Nov 14. - Publication Year :
- 2015
-
Abstract
- Aims/hypothesis: Childhood obesity is a major public health problem in Mexico, affecting one in every three children. Genome-wide association studies identified genetic variants associated with childhood obesity, but a large missing heritability remains to be elucidated. We have recently shown a strong association between a highly polymorphic copy number variant encompassing the salivary amylase gene (AMY1 also known as AMY1A) and obesity in European and Asian adults. In the present study, we aimed to evaluate the association between AMY1 copy number and obesity in Mexican children.<br />Methods: We evaluated the number of AMY1 copies in 597 Mexican children (293 obese children and 304 normal weight controls) through highly sensitive digital PCR. The effect of AMY1 copy number on obesity status was assessed using a logistic regression model adjusted for age and sex.<br />Results: We identified a marked effect of AMY1 copy number on reduced risk of obesity (OR per estimated copy 0.84, with the number of copies ranging from one to 16 in this population; p = 4.25 × 10(-6)). The global association between AMY1 copy number and reduced risk of obesity seemed to be mostly driven by the contribution of the highest AMY1 copy number. Strikingly, all children with >10 AMY1 copies were normal weight controls.<br />Conclusions/interpretation: Salivary amylase initiates the digestion of dietary starch, which is highly consumed in Mexico. Our current study suggests putative benefits of high number of AMY1 copies (and related production of salivary amylase) on energy metabolism in Mexican children.
- Subjects :
- Body Mass Index
Child
Female
Genetic Predisposition to Disease genetics
Genetic Variation
Genome-Wide Association Study
Humans
Logistic Models
Male
Mexico epidemiology
Obesity epidemiology
Public Health
Salivary alpha-Amylases genetics
Carbohydrate Metabolism genetics
Obesity genetics
Salivary alpha-Amylases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0428
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 25394825
- Full Text :
- https://doi.org/10.1007/s00125-014-3441-3