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Ultraviolet index and location are important determinants of vitamin D status in people with human immunodeficiency virus.
- Source :
-
Photochemistry and photobiology [Photochem Photobiol] 2015 Mar-Apr; Vol. 91 (2), pp. 431-7. Date of Electronic Publication: 2014 Dec 09. - Publication Year :
- 2015
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Abstract
- This study aimed to document the vitamin D status of HIV-infected individuals across a wide latitude range in one country and to examine associated risk factors for low vitamin D. Using data from patients attending four HIV specialist clinics across a wide latitude range in Australia, we constructed logistic regression models to investigate risk factors associated with 25(OH)D < 75 nmol L(-1). 1788 patients were included; 87% were male, 76% Caucasian and 72% on antiretroviral therapy. The proportion with 25(OH)D < 50 nmol L(-1) was 27%, and <75 nmol L(-1) was 54%. Living in Melbourne compared with Cairns (adjusted odds ratio (aOR) 3.30; 95% CI 2.18, 4.99, P < 0.001) and non-Caucasian origin (aOR 2.82, 95% CI 2.12, 3.75, P < 0.001) was associated with an increased risk, while extreme UV index compared with low UV index was associated with a reduced risk (aOR 0.33; 95% CI 0.20, 0.55, P < 0.001) of 25(OH)D < 75 nmol L(-1). In those with biochemistry available (n = 1117), antiretroviral therapy was associated with 25(OH)D < 75 nmol L(-1); however, this association was modified by serum cholesterol status. Location and UV index were the strongest factors associated with 25(OH)D < 75 nmol L(-1). Cholesterol, the product of an alternative steroid pathway with a common precursor steroid, modified the effect of antiretroviral therapy on serum 25(OH)D.<br /> (© 2014 The American Society of Photobiology.)
- Subjects :
- Adult
Australia
Cholesterol blood
Cities
Cross-Sectional Studies
Female
Geography
HIV drug effects
HIV Infections complications
HIV Infections drug therapy
HIV Infections immunology
Humans
Male
Middle Aged
Racial Groups
Retrospective Studies
Risk Factors
Ultraviolet Rays
Vitamin D Deficiency complications
Vitamin D Deficiency drug therapy
Vitamin D Deficiency immunology
Antiretroviral Therapy, Highly Active
Calcifediol blood
HIV immunology
HIV Infections blood
Vitamin D Deficiency blood
Subjects
Details
- Language :
- English
- ISSN :
- 1751-1097
- Volume :
- 91
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Photochemistry and photobiology
- Publication Type :
- Academic Journal
- Accession number :
- 25400107
- Full Text :
- https://doi.org/10.1111/php.12390