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Prognostic significance of microRNA-375 downregulation in solid tumors: a meta-analysis.
- Source :
-
Disease markers [Dis Markers] 2014; Vol. 2014, pp. 626185. Date of Electronic Publication: 2014 Oct 23. - Publication Year :
- 2014
-
Abstract
- Objective: Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. We performed a meta-analysis to evaluate the impact of miR-375 expression in solid tumors on patients' overall survival (OS).<br />Methods: Studies were identified by searching PubMed, Embace, and Cochrane Library (last search update was in May 2014) and were assessed by further quality evaluation. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for total and stratified analyses were calculated to investigate the association between miR-375 expression and cancer patients OS.<br />Results: Our analysis results indicated that downregulation of miR-375 predicted poor OS (HR = 1.91, 95% CI 1.48-2.45, P < 0.001). Subgroup analyses showed that lower expression of miR-375 was significantly related with poor OS in patients with esophageal carcinoma (HR = 2.24, 95% CI 1.69-2.96, P < 0.001) and non-small-cell lung cancer (NSCLC) (HR = 1.71, 95% CI 1.31-2.24, P < 0.001).<br />Conclusions: The findings from this meta-analysis suggest that miR-375 expression is associated with OS of patients with malignant tumors and could be a useful clinical prognostic biomarker.
- Subjects :
- Biomarkers, Tumor genetics
Carcinoma diagnosis
Carcinoma, Non-Small-Cell Lung diagnosis
Case-Control Studies
Esophageal Neoplasms diagnosis
Humans
MicroRNAs genetics
Prognosis
Biomarkers, Tumor metabolism
Carcinoma metabolism
Carcinoma, Non-Small-Cell Lung metabolism
Down-Regulation
Esophageal Neoplasms metabolism
MicroRNAs metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8630
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- Disease markers
- Publication Type :
- Academic Journal
- Accession number :
- 25404787
- Full Text :
- https://doi.org/10.1155/2014/626185