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Amphiphilic star block copolymers as gene carrier part I: synthesis via ATRP using calix[4]resorcinarene-based initiators and characterization.
- Source :
-
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2013 Jan 01; Vol. 33 (1), pp. 519-26. Date of Electronic Publication: 2012 Oct 04. - Publication Year :
- 2013
-
Abstract
- In this work, a cationic star polymer [poly(2-dimethylamino)ethyl methacrylate (PDMAEMA)] was prepared via atom transfer radical polymerization (ATRP), using brominated calix[4]resorcinarene as an initiator. Hydrophobic moieties, methyl methacrylate (MMA) and butyl acrylate (BA), were further incorporated via "one-pot" method. Well-defined eight-armed star block copolymers bearing hydrophilic blocks inside and hydrophobic blocks outside were synthesized. The molecular weight, particle size, electrophoretic mobility and apparent charge density were determined by gel permeation chromatography (GPC), dynamic light scattering (DLS), phase analysis light scattering (PALS) and colloidal titration, respectively. The zeta potentials and apparent charge densities of the products exhibited the characteristics of polyelectrolyte. The incorporation of hydrophobic moieties generated electrostatic screening effect. The as-synthesized amphiphilic star copolymer is promising as a thermo-sensitive gene carrier for gene therapy.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Calixarenes chemical synthesis
Chromatography, Gel
Electrophoresis
Kinetics
Methacrylates chemical synthesis
Methylmethacrylate chemistry
Nylons chemical synthesis
Particle Size
Phenylalanine chemical synthesis
Phenylalanine chemistry
Proton Magnetic Resonance Spectroscopy
Static Electricity
Calixarenes chemistry
Methacrylates chemistry
Nylons chemistry
Phenylalanine analogs & derivatives
Polymerization
Subjects
Details
- Language :
- English
- ISSN :
- 1873-0191
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Materials science & engineering. C, Materials for biological applications
- Publication Type :
- Academic Journal
- Accession number :
- 25428104
- Full Text :
- https://doi.org/10.1016/j.msec.2012.09.024