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What is the next generation therapeutic strategy for castration-resistant prostate cancer.
- Source :
-
Asian journal of andrology [Asian J Androl] 2015 Mar-Apr; Vol. 17 (2), pp. 223-4. - Publication Year :
- 2015
-
Abstract
- Prostate cancer (PCa) is one of the most common cancers in the world. Since androgen receptor (AR) signal plays key roles in the PCa progression, targeting androgens via the current androgen deprivation therapy (ADT) is the main therapeutic strategy for advanced PCa. However, most patients who receive ADT, including the second generation anti-androgens enzalutamide (also known as MDV3100) may finally develop the castration (or anti-androgen) resistance after 12-24 months treatment. In the manuscript by Asangani et al., the authors demonstrated that targeting the amino-terminal bromodomains of BRD4 could preferentially suppress human castration-resistant prostate cancer (CRPC) cell lines. While further studies are required to understand the full impact of their findings, the innovative approach provides a potential novel epigenetic approach for the concerted blockade of oncogenic drivers in CRPC.
Details
- Language :
- English
- ISSN :
- 1745-7262
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Asian journal of andrology
- Publication Type :
- Academic Journal
- Accession number :
- 25432503
- Full Text :
- https://doi.org/10.4103/1008-682X.143311