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Immunohistochemical HER2 expression not associated with clinicopathological characteristics of stage I-III gastric cancer patients.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2014 Sep; Vol. 61 (134), pp. 1817-21. - Publication Year :
- 2014
-
Abstract
- Background/aims: The aim of this study was to investigate the association of human epidermal growth factor receptor 2 (HER2) expression with clinicopathological characteristics of resectable gastric cancer patients.<br />Methodology: A total of 394 stage I-III surgical gastric cancer patients who were detected of immunohistochemical (IHC) HER2 expression postoperatively were included in this retrospective study. Association of IHC HER2 over-expression (3+) rate with clinicopathological characteristics was tested by univariate and multivariate analyses.<br />Results: IHC HER2 over-expression rate was 5.1% (95% CI 3.1%-7.7%). By univariate analyses, none of the clinicopathological characteristics was associated with the IHC HER2 over-expression compared to negative expression (0/1+) (p>0.05), with the exception of a higher rate (12.2%) of IHC HER2 (3+) in moderate differentiation subset (p=0.02). However, the multivariate analyses didn’t selected any characteristic as an independent risk factor of IHC HER2 over-expression or the combination of IHC HER2 (2/3+).<br />Conclusions: IHC HER2 over-expression rate is relatively low among stage I-III gastric cancer patients, and might be generally not associated with clinicopathological characteristics.
- Subjects :
- Adult
Aged
Aged, 80 and over
Chi-Square Distribution
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Odds Ratio
Predictive Value of Tests
Retrospective Studies
Risk Factors
Stomach Neoplasms pathology
Stomach Neoplasms surgery
Up-Regulation
Biomarkers, Tumor analysis
Immunohistochemistry
Receptor, ErbB-2 analysis
Stomach Neoplasms enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 61
- Issue :
- 134
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25436385