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Site selective activation of lateral hypothalamic mGluR1 and R5 receptors elicits feeding in rats.
- Source :
-
Physiology & behavior [Physiol Behav] 2015 Feb; Vol. 139, pp. 261-6. Date of Electronic Publication: 2014 Nov 18. - Publication Year :
- 2015
-
Abstract
- Recent findings from our lab indicate that metabotropic glutamate receptor (mGluR) activation elicits eating, and the goal of the current study was to specify whether the lateral hypothalamus (LH) is the actual brain site mediating this effect. To examine this issue we injected the selective mGluR group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) unilaterally into the LH and surrounding regions (n=5-8 subjects/brain site) of satiated adult male Sprague-Dawley rats and measured elicited feeding. We determined that 1.0 nmol elicited food intake only within the LH. Increasing the dose to 10 or 25 nmol produced a more sustained effect in the LH, and also elicited eating in several other brain sites. These results, demonstrating that the LH mediates the eating elicited by low doses of DHPG, suggest that the LH may contain mGluR whose activation can produce eating behavior.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Amygdala drug effects
Amygdala physiology
Animals
Dose-Response Relationship, Drug
Eating drug effects
Excitatory Amino Acid Agonists pharmacology
Glycine analogs & derivatives
Glycine pharmacology
Hypothalamic Area, Lateral drug effects
Male
Mediodorsal Thalamic Nucleus drug effects
Mediodorsal Thalamic Nucleus physiology
Rats, Sprague-Dawley
Receptor, Metabotropic Glutamate 5 agonists
Receptors, Metabotropic Glutamate agonists
Resorcinols pharmacology
Satiation drug effects
Satiation physiology
Substantia Nigra drug effects
Substantia Nigra physiology
Thalamus drug effects
Thalamus physiology
Eating physiology
Hypothalamic Area, Lateral physiology
Receptor, Metabotropic Glutamate 5 metabolism
Receptors, Metabotropic Glutamate metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-507X
- Volume :
- 139
- Database :
- MEDLINE
- Journal :
- Physiology & behavior
- Publication Type :
- Academic Journal
- Accession number :
- 25449406
- Full Text :
- https://doi.org/10.1016/j.physbeh.2014.10.039