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Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus.
- Source :
-
Peptides [Peptides] 2015 Jan; Vol. 63, pp. 38-42. Date of Electronic Publication: 2014 Nov 08. - Publication Year :
- 2015
-
Abstract
- The main bacterium associated with skin infection is Staphylococcus aureus, occurring especially in infections acquired via surgical wounds, commonly leading to lethal hospital-acquired infections, emphasizing the importance of identifying new antimicrobial compounds. Among them, cyclotides have gained interest due to their high stability and multifunctional properties. Here, cycloviolacin 2 (CyO2) and kalata B2 (KB2) were evaluated to determinate their anti-staphylococcal activities using a subcutaneous infection model. Anti-staphylococcal activities of 50mM for KB2 and 25mM for CyO2 were detected with no cytotoxic activities against RAW 264.7 monocytes. In the in vivo assays, both cyclotides reduced bacterial load and CyO2 demonstrated an increase in the phagocytosis index, suggesting that the CyO2 in vivo anti-staphylococcal activity may be associated with phagocytic activity, additionally to direct anti-pathogenic activity.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Mice
Mice, Inbred C57BL
Microbial Sensitivity Tests
Microbial Viability
Neutrophils drug effects
Neutrophils physiology
Phagocytosis drug effects
RAW 264.7 Cells
Staphylococcal Skin Infections microbiology
Surgical Wound Infection microbiology
Anti-Bacterial Agents pharmacology
Peptides, Cyclic pharmacology
Staphylococcal Skin Infections drug therapy
Staphylococcus aureus drug effects
Surgical Wound Infection drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5169
- Volume :
- 63
- Database :
- MEDLINE
- Journal :
- Peptides
- Publication Type :
- Academic Journal
- Accession number :
- 25451333
- Full Text :
- https://doi.org/10.1016/j.peptides.2014.10.019