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Analysis of blood leukocytes in a naturally occurring immunodeficiency of pigs shows the defect is localized to B and T cells.
- Source :
-
Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2014 Dec 15; Vol. 162 (3-4), pp. 174-9. Date of Electronic Publication: 2014 Oct 14. - Publication Year :
- 2014
-
Abstract
- Severe combined immunodeficiency (SCID) is the result of a set of inherited genetic defects which render components of the immune response nonfunctional. In Arabian horses, Jack Russell terriers, and mice, the disorder is a consequence of the absence of T and B lymphocytes, while natural killer (NK) cell and other leukocyte populations remain intact. Preliminary analysis of a naturally acquired form of inherited SCID in a line of pigs showed several defects in the architecture and composition of secondary lymphoid organs. In this study, a quantitative assessment of lymphocyte populations in affected and normal littermates showed depleted T or B lymphocyte populations in affected pigs; however, NK cells and neutrophils were present in numbers comparable to unaffected littermates. The results indicate that the immune defect in pigs shares the same features as other SCID-affected species.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Histocytochemistry veterinary
Lymphocyte Count veterinary
Severe Combined Immunodeficiency blood
Severe Combined Immunodeficiency immunology
Swine
Swine Diseases blood
B-Lymphocytes immunology
Lymphoid Tissue immunology
Severe Combined Immunodeficiency veterinary
Swine Diseases immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2534
- Volume :
- 162
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Veterinary immunology and immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 25454085
- Full Text :
- https://doi.org/10.1016/j.vetimm.2014.10.003