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Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2014 Dec; Vol. 74, pp. 225-32. - Publication Year :
- 2014
-
Abstract
- Alcohol consumption is customary in many cultures and it is a common human behavior worldwide. Binge ethanol and chronic alcohol consumption, two usual drinking patterns of human beings, produce a state of oxidative stress in liver and disturb the liver function. However, a safe and effective therapy for alcoholic liver disease in humans is still elusive. This study identified the natural product berberine as a potential agent for treating or preventing ethanol-induced liver injury. We demonstrated that berberine attenuated oxidative stress resulted from binge drinking in liver by reducing hepatic lipid peroxidation, glutathione exhaust and mitochondrial oxidative damage. Furthermore, berberine also prevented the oxidative stress and macrosteatosis in response to chronic ethanol exposure in mice. Either the total cytochrome P450 2E1 or the mitochondria-located cytochrome P450 2E1, which is implicated in ethanol-mediated oxidative stress, was suppressed by berberine. On the other hand, berberine significantly blunted the lipid accumulation in liver due to chronic alcohol consumption, at least partially, through restoring peroxisome proliferator-activated receptor α/peroxisome proliferator-activated receptor-gamma Co-activator-1α and hepatocyte nuclear factor 4α/microsomal triglyceride transfer protein pathways. These findings suggested that berberine could serve as a potential agent for preventing or treating human alcoholic liver disease.
- Subjects :
- Animals
Apoptosis drug effects
Binge Drinking pathology
Lipid Metabolism drug effects
Male
Mice
Mice, Inbred ICR
Mitochondria, Liver drug effects
Mitochondrial Swelling drug effects
Signal Transduction drug effects
Berberine pharmacology
Central Nervous System Depressants antagonists & inhibitors
Central Nervous System Depressants toxicity
Ethanol antagonists & inhibitors
Ethanol toxicity
Fatty Liver, Alcoholic prevention & control
Liver Diseases, Alcoholic prevention & control
Oxidative Stress drug effects
Protective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 74
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 25455889
- Full Text :
- https://doi.org/10.1016/j.fct.2014.10.005