Back to Search
Start Over
Postoperative radiotherapy for laryngeal carcinoma: the prognostic role of subcellular Maspin expression.
- Source :
-
American journal of otolaryngology [Am J Otolaryngol] 2015 Mar-Apr; Vol. 36 (2), pp. 184-9. Date of Electronic Publication: 2014 Oct 22. - Publication Year :
- 2015
-
Abstract
- Purpose: Reported outcomes of postoperative radiotherapy (PORT) for laryngeal squamous cell carcinoma (LSCC) have varied and sometimes been disappointing. The aim of the present preliminary study was to investigate whether a given immunohistochemical pattern of Maspin expression in laryngeal carcinoma cells could be prognostically associated with response to PORT.<br />Materials and Methods: Thirty-two consecutive patients treated for LSCC with primary surgery and PORT. The subcellular (nuclear vs non-nuclear) pattern of Maspin expression was assessed immunohistochemically on LSCC surgical specimens and analyzed in relation to recurrence rate (RR) and disease-free survival (DFS).<br />Results: A non-nuclear Maspin expression was found in 23 of 32 cases (72%), and all recurrences (17 cases) occurred in this subgroup of patients. A non-nuclear Maspin expression was strongly associated with recurrence [p = 0.0002, hazard ratio (HR) 5.58] and a shorter DFS (p = 0.0004) after PORT for LSCC. Even in N0 patients, a non-nuclear Maspin expression was associated with a significantly higher RR (p = 0.04, HR 1.42) and a shorter DFS (p = 0.02). Among the common clinic-pathological parameters considered, only N stage showed a trend toward an association with prognosis in terms of DFS (p = 0.08).<br />Conclusion: Assessing subcellular patterns of Maspin expression in LSCC specimens could identify patients less likely to respond to PORT, who might benefit from combined chemo-radiotherapy to improve the efficacy of adjuvant protocols.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell surgery
Cohort Studies
Disease-Free Survival
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Laryngeal Neoplasms genetics
Laryngeal Neoplasms mortality
Laryngeal Neoplasms surgery
Laryngectomy methods
Male
Middle Aged
Neoplasm Invasiveness pathology
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Postoperative Period
Prognosis
Proportional Hazards Models
Prospective Studies
Radiotherapy, Adjuvant
Risk Assessment
Statistics, Nonparametric
Survival Rate
Treatment Outcome
Carcinoma, Squamous Cell radiotherapy
Gene Expression Regulation, Neoplastic
Laryngeal Neoplasms radiotherapy
Neoplasm Recurrence, Local mortality
Serpins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-818X
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of otolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 25459315
- Full Text :
- https://doi.org/10.1016/j.amjoto.2014.10.027