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Does ambient CO have protective effect for COPD patient?
- Source :
-
Environmental research [Environ Res] 2015 Jan; Vol. 136, pp. 21-6. Date of Electronic Publication: 2014 Nov 19. - Publication Year :
- 2015
-
Abstract
- Background: Existing studies found paradoxical effects of carbon monoxide (CO) on human health. Carbon monoxide (CO), at high concentrations, is a well-known toxicant, but recent studies suggest that CO at low concentrations may have protective health effects under certain conditions.<br />Objectives: To investigate the acute effect of ambient CO on hospital admission for chronic obstructive pulmonary disease (COPD) in Shanghai, China.<br />Methods: Daily data on COPD admissions and CO concentrations between 2006 and 2008 were collected. We applied over-dispersed generalized additive Poisson models, adjusted for weather conditions, day of the week and public holidays, long-term and seasonal trends.<br />Results: During the study period, the average CO concentration was 1.3mg/m(3), well below the international health-based standard. Negative associations were found between ambient CO concentration and daily COPD hospitalization. An interquartile range increase (0.6 mg/m(3)) in CO concentration at lag 3 day corresponded to -2.97% (95% confidence interval: -4.63%, -1.31%) change in COPD hospitalization. The negative associations were robust after adjustment for co-pollutants (PM10, NO2 and SO2). The protective effect of CO appeared to be more evident in the cool season.<br />Conclusion: Short-term exposure to CO at low ambient concentration may be associated with reduced risk of COPD hospitalization. Our results may contribute to a comprehensive understanding on the health effects of ambient CO.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1096-0953
- Volume :
- 136
- Database :
- MEDLINE
- Journal :
- Environmental research
- Publication Type :
- Academic Journal
- Accession number :
- 25460616
- Full Text :
- https://doi.org/10.1016/j.envres.2014.09.039