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Post-modern pathogens: surprising activities of translocated effectors from E. coli and Legionella.
- Source :
-
Current opinion in microbiology [Curr Opin Microbiol] 2015 Feb; Vol. 23, pp. 73-9. Date of Electronic Publication: 2014 Nov 25. - Publication Year :
- 2015
-
Abstract
- Many bacterial pathogens have the ability to manipulate cellular processes and interfere with host cell function through the translocation of bacterial 'effector' proteins. Dedicated protein secretion machines from Gram-negative pathogens, including type III, type IV and type VI secretion systems, inject virulence proteins into infected cells, altering normal cell physiology, including cell structure, metabolism, trafficking and signalling. While effectors were once thought to exert an effect simply by their localization and binding to host cell proteins, increasingly effectors are being recognised as enzymes, in some cases mediating highly novel post-translational modifications on host proteins. Here we highlight some of the more unusual activities of translocated effectors from enteropathogenic Escherichia coli and Legionella pneumophila.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Bacterial Secretion Systems
Escherichia coli growth & development
Host-Pathogen Interactions
Humans
Legionella pneumophila growth & development
Protein Transport
Bacterial Proteins metabolism
Cell Physiological Phenomena drug effects
Escherichia coli metabolism
Legionella pneumophila metabolism
Virulence Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0364
- Volume :
- 23
- Database :
- MEDLINE
- Journal :
- Current opinion in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 25461576
- Full Text :
- https://doi.org/10.1016/j.mib.2014.11.005