Back to Search
Start Over
Clinical validation of FDG-PET/CT in the radiation treatment planning for patients with oesophageal cancer.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2014 Nov; Vol. 113 (2), pp. 188-92. Date of Electronic Publication: 2014 Nov 29. - Publication Year :
- 2014
-
Abstract
- Background: The aim of this prospective study was to determine the proportion of locoregional recurrences (LRRs) that could have been prevented if radiotherapy treatment planning for oesophageal cancer was based on PET/CT instead of CT.<br />Materials and Methods: Ninety oesophageal cancer patients, eligible for high dose (neo-adjuvant) (chemo)radiotherapy, were included. All patients underwent a planning FDG-PET/CT-scan. Radiotherapy target volumes (TVs) were delineated on CT and patients were treated according to the CT-based treatment plans. The PET images remained blinded. After treatment, TVs were adjusted based on PET/CT, when appropriate. Follow up included CT-thorax/abdomen every 6months. If LRR was suspected, a PET/CT was conducted and the site of recurrence was compared to the original TVs. If the LRR was located outside the CT-based clinical TV (CTV) and inside the PET/CT-based CTV, we considered this LRR possibly preventable.<br />Results: Based on PET/CT, the gross tumour volume (GTV) was larger in 23% and smaller in 27% of the cases. In 32 patients (36%), >5% of the PET/CT-based GTV would be missed if the treatment planning was based on CT. The median follow up was 29months. LRRs were seen in 10 patients (11%). There were 3 in-field recurrences, 4 regional recurrences outside both CT-based and PET/CT-based CTV and 3 recurrences at the anastomosis without changes in TV by PET/CT; none of these recurrences were considered preventable by PET/CT.<br />Conclusion: No LRR was found after CT-based radiotherapy that could have been prevented by PET/CT. The value of PET/CT for radiotherapy seems limited.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Multimodal Imaging methods
Neoplasm Recurrence, Local diagnosis
Positron-Emission Tomography methods
Prospective Studies
Radiotherapy Dosage
Radiotherapy, Conformal methods
Tomography, X-Ray Computed methods
Esophageal Neoplasms diagnostic imaging
Esophageal Neoplasms radiotherapy
Fluorodeoxyglucose F18
Neoplasm Recurrence, Local prevention & control
Radiopharmaceuticals
Radiotherapy Planning, Computer-Assisted methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 113
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25467002
- Full Text :
- https://doi.org/10.1016/j.radonc.2014.10.016