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Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis.
- Source :
-
Molecular and clinical oncology [Mol Clin Oncol] 2015 Jan; Vol. 3 (1), pp. 125-132. Date of Electronic Publication: 2014 Sep 18. - Publication Year :
- 2015
-
Abstract
- This study was conducted to determine the prognostic value of serum α-fetoprotein (AFP) levels in patients with ovarian yolk sac tumor (OYST). We performed a systematic review and meta-analysis to assess the associations between serum AFP level and prognosis in OYST. A total of 12 quantitative studies met the inclusion criteria. Preoperative AFP was not found to be associated with overall survival (OS) [odds ratio (OR)=0.84, 95% confidence interval (CI): 0.43-1.62] in OYST. However, a high postoperative AFP level was associated with worse OS (OR=0.16, 95% CI: 0.05-0.48) and relapse-free survival (RFS) (OR=0.18, 95% CI: 0.08-0.43) compared to a low postoperative AFP level in patients with OYST. In addition, a postoperative AFP level of >1,000 ng/ml was associated with a decrease in OS (OR=0.16, 95% CI: 0.05-0.50) and RFS (OR=0.21, 95% CI: 0.08-0.57). In conclusion, the postoperative, but not the preoperative, AFP level was found to be a prognostic factor in patients with OYST. In particular, a postoperative AFP level of >1,000 ng/ml was an indicator of poor prognosis in patients with OYST.
Details
- Language :
- English
- ISSN :
- 2049-9450
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25469282
- Full Text :
- https://doi.org/10.3892/mco.2014.417