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Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2015 Feb 07; Vol. 13 (5), pp. 1500-6. - Publication Year :
- 2015
-
Abstract
- In this work, we describe an accelerated solid-phase synthetic protocol for ordinary or difficult peptides involving air-bath heating and amide protection. For the Hmsb-based backbone amide protection, an optimized acyl shift condition using 1,4-dioxane was discovered. The efficiency and robustness of the protocol was validated in the course of preparation of classical difficult peptides and ubiquitin protein segments.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25476596
- Full Text :
- https://doi.org/10.1039/c4ob02260b