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Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a proton magnetic resonance spectroscopy study.
- Source :
-
Schizophrenia research [Schizophr Res] 2015 Feb; Vol. 161 (2-3), pp. 202-9. Date of Electronic Publication: 2014 Dec 03. - Publication Year :
- 2015
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Abstract
- Background: Superior temporal cortices include brain regions dedicated to auditory processing and several lines of evidence suggest structural and functional abnormalities in both schizophrenia and bipolar disorder within this brain region. However, possible glutamatergic dysfunction within this region has not been investigated in adult patients.<br />Methods: Thirty patients with schizophrenia (38.67±12.46years of age), 28 euthymic patients with bipolar I disorder (35.32±9.12years of age), and 30 age-, gender- and education-matched healthy controls were enrolled. Proton magnetic resonance spectroscopy data were acquired using a 3.0T Siemens MAGNETOM TIM Trio MR system and single voxel Point REsolved Spectroscopy Sequence (PRESS) in order to quantify brain metabolites within the left and right Heschl's gyrus and planum temporale of superior temporal cortices.<br />Results: There were significant abnormalities in glutamate (Glu) (F(2,78)=8.52, p<0.0001), N-acetyl aspartate (tNAA) (F(2,81)=5.73, p=0.005), creatine (tCr) (F(2,83)=5.91, p=0.004) and inositol (Ins) (F(2,82)=8.49, p<0.0001) concentrations in the left superior temporal cortex. In general, metabolite levels were lower for bipolar disorder patients when compared to healthy participants. Moreover, patients with bipolar disorder exhibited significantly lower tCr and Ins concentrations when compared to schizophrenia patients. In addition, we have found significant correlations between the superior temporal cortex metabolites and clinical measures.<br />Conclusion: As the left auditory cortices are associated with language and speech, left hemisphere specific abnormalities may have clinical significance. Our findings are suggestive of shared glutamatergic abnormalities in schizophrenia and bipolar disorder.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Analysis of Variance
Aspartic Acid metabolism
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Proton Magnetic Resonance Spectroscopy
Young Adult
Aspartic Acid analogs & derivatives
Auditory Cortex metabolism
Bipolar Disorder pathology
Creatine metabolism
Schizophrenia pathology
Temporal Lobe metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2509
- Volume :
- 161
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 25480359
- Full Text :
- https://doi.org/10.1016/j.schres.2014.11.012