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Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Jan 15; Vol. 25 (2), pp. 313-6. Date of Electronic Publication: 2014 Nov 22. - Publication Year :
- 2015
-
Abstract
- 5-(4'-Methoxyphenyl)-oxazole (MPO), originally reported as a synthetic compound, was isolated from fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chemically synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Bacteria drug effects
Cells, Cultured
Fungi drug effects
Germ Cells cytology
Germ Cells drug effects
HeLa Cells
Humans
Molecular Structure
Structure-Activity Relationship
Antinematodal Agents chemical synthesis
Antinematodal Agents pharmacology
Caenorhabditis elegans drug effects
Caenorhabditis elegans growth & development
Oxazoles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 25488842
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.11.042