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IIb group metal ions (Zn2+, Cd2+, Hg2+) stimulate glucose transport activity by post-insulin receptor kinase mechanism in rat adipocytes.
- Source :
-
The Journal of biological chemistry [J Biol Chem] 1989 Sep 25; Vol. 264 (27), pp. 16118-22. - Publication Year :
- 1989
-
Abstract
- Zn2+ (1 mM), Cd2+ (1 mM), and Hg2+ (0.1 mM) belonging to the IIb group in the periodic table stimulated glucose transport activity and cAMP phosphodiesterase in rat adipocytes. The stimulation of glucose transport was due to the translocation of glucose transporters from the intracellular site to the plasma membrane. However, in intact adipocytes none of these ions stimulated insulin receptor kinase activity or phosphorylation of the 95-kDa subunit of insulin receptor or 170- or 60-kDa proteins at the tyrosyl residues. These proteins were markedly phosphorylated by addition of 0.3 nM insulin which stimulated glucose transport activity as effectively as these metal ions. These results indicate that Zn2+, Cd2+, and Hg2+ mimic insulin action by a post-receptor/kinase mechanism.
- Subjects :
- 3-O-Methylglucose
Adipose Tissue drug effects
Animals
Cells, Cultured
Kinetics
Male
Rats
Rats, Inbred Strains
Subcellular Fractions metabolism
Adipose Tissue metabolism
Cadmium pharmacology
Insulin pharmacology
Mercury pharmacology
Methylglucosides metabolism
Methylglycosides metabolism
Monosaccharide Transport Proteins metabolism
Protein-Tyrosine Kinases metabolism
Receptor, Insulin metabolism
Zinc pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9258
- Volume :
- 264
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- The Journal of biological chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 2550432