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Y-shaped biotin-conjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin.
- Source :
-
Journal of colloid and interface science [J Colloid Interface Sci] 2015 Apr 01; Vol. 443, pp. 1-7. Date of Electronic Publication: 2014 Dec 06. - Publication Year :
- 2015
-
Abstract
- In order to improve curcumin's low water-solubility and selective delivery to cancer, we reported ligand-mediated micelles based on a Y-shaped biotin-poly (ethylene glycol)-poly (epsilon-caprolactone)2 (biotin-PEG-PCL2) copolymer. Its structure was characterized by (1)H NMR. The blank and drug-loaded micelles obtained by way of thin-film hydration were characterized by dynamic light scattering, X-ray diffraction, infrared spectroscopy and hemolytic test. Curcumin was loaded into micelles with a high encapsulating efficiency (93.83%). Curcumin's water-solubility was enhanced 170,400 times higher than free curcumin. Biotin-PEG-PCL2 micelles showed slower drug release in vitro than H2N-PEG-PCL2 micelles. In vitro cellular uptake and cytotoxicity tests showed that higher dosage of curcumin might overcome the effect of slow release on cytotoxicities because of its higher uptake induced by biotin, resulting in higher anticancer activities against MDA-MB-436 cells. In brief, Y-shaped biotin-PEG-PCL2 is a promising delivery carrier for anticancer drug.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Breast Neoplasms pathology
Cell Proliferation drug effects
Drug Carriers
Female
Humans
Micelles
Molecular Structure
Tumor Cells, Cultured
Antineoplastic Agents administration & dosage
Biotin chemistry
Breast Neoplasms drug therapy
Curcumin administration & dosage
Drug Delivery Systems
Ethylene Glycols chemistry
Polyesters chemistry
Polymers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1095-7103
- Volume :
- 443
- Database :
- MEDLINE
- Journal :
- Journal of colloid and interface science
- Publication Type :
- Academic Journal
- Accession number :
- 25526295
- Full Text :
- https://doi.org/10.1016/j.jcis.2014.11.073