Back to Search
Start Over
Quantitative computed tomographic assessment of bone mineral density changes associated with administration of prednisolone or prednisolone and alendronate sodium in dogs.
- Source :
-
American journal of veterinary research [Am J Vet Res] 2015 Jan; Vol. 76 (1), pp. 28-34. - Publication Year :
- 2015
-
Abstract
- Objective: To evaluate whether a low-dosage regimen of prednisolone induces bone loss and whether administration of alendronate sodium prevents glucocorticoid-induced osteopenia in dogs by measuring trabecular bone mineral density (BMD) with quantitative CT.<br />Animals: 8 healthy Beagles.<br />Procedures: In 4 dogs, prednisolone was administered PO at a dosage of 2 mg/kg once daily for 2 weeks, 1 mg/kg once daily for 4 weeks, and 0.5 mg/kg once daily for 3 weeks. In the other 4 dogs, alendronate sodium (2 mg/kg, PO, q 24 h) was whether administered for 9 weeks in addition to the same dosage of prednisolone used in the prednisolone-treated dogs. Before (day 0 [baseline]) and 21, 42, 63, and 150 days after the start of treatment, BMD of the lumbar vertebrae was measured by quantitative CT.<br />Results: BMD in the prednisolone treatment group decreased to 84.7% of the baseline value on day 42, increased to 87.9% on day 63, and recovered to 91.6% on day 150. In the prednisolone-alendronate treatment group, BMD decreased to 91% of the baseline value on day 21, increased to 93.8% on day 63, and then recovered to 96.7% on day 150. Bone mineral density in the prednisolone treatment group was generally lower, albeit not significantly, than that of the prednisolone-alendronate treatment group on each examination day.<br />Conclusions and Clinical Relevance: BMD temporarily decreased after low-dosage prednisolone administration; however, it gradually improved during tapering of the prednisolone dosage. These results have suggested that a low dosage of prednisolone can be used with little concern for development of osteopenia in dogs.
- Subjects :
- Administration, Oral
Animals
Dog Diseases chemically induced
Dogs
Dose-Response Relationship, Drug
Drug Administration Schedule
Glucocorticoids adverse effects
Lumbar Vertebrae diagnostic imaging
Male
Osteoporosis prevention & control
Osteoporosis veterinary
Prednisolone adverse effects
Tomography, X-Ray Computed veterinary
Alendronate pharmacology
Bone Density drug effects
Bone Density Conservation Agents pharmacology
Dog Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1943-5681
- Volume :
- 76
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 25535658
- Full Text :
- https://doi.org/10.2460/ajvr.76.1.28