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Effects of B-type natriuretic peptide on cardiovascular biomarkers in healthy volunteers.
- Source :
-
Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2015 Feb 15; Vol. 118 (4), pp. 395-9. Date of Electronic Publication: 2014 Dec 24. - Publication Year :
- 2015
-
Abstract
- Cardiovascular biomarkers provide independent prognostic information in the assessment of mortality and cardiovascular complications. However, little is known about possible interactions between these biomarkers. In the present study, we evaluated the influence of B-type natriuretic peptide (BNP) on midregional-proadrenomedullin (MR-proADM), C-terminal-proendothelin-1 (CT-proET-1), growth differentiation factor-15 (GDF-15), midregional-proatrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin in healthy volunteers. Ten healthy male subjects (mean age 24 yr) participating in a randomized, placebo-controlled, single-blinded crossover study received placebo or 3.0 pmol·kg(-1)·min(-1) human BNP 32 during a continuous infusion lasting for 4 h. Effects of BNP on other cardiovascular biomarkers were assessed. BNP did not change concentrations of MR-proADM, copeptin, CT-proET1, GDF-15, or procalcitonin. In contrast, MR-proANP was significantly decreased during BNP infusion. BNP as an established cardiovascular biomarker did not affect plasma concentrations of other cardiovascular biomarkers in a model of healthy volunteers.<br /> (Copyright © 2015 the American Physiological Society.)
- Subjects :
- Adrenomedullin metabolism
Adult
Atrial Natriuretic Factor metabolism
Calcitonin metabolism
Calcitonin Gene-Related Peptide
Cross-Over Studies
Endothelin-1 metabolism
Glycopeptides metabolism
Growth Differentiation Factor 15 metabolism
Healthy Volunteers
Humans
Male
Peptide Fragments metabolism
Protein Precursors metabolism
Young Adult
Biomarkers metabolism
Cardiovascular System metabolism
Natriuretic Peptide, Brain metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1601
- Volume :
- 118
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of applied physiology (Bethesda, Md. : 1985)
- Publication Type :
- Academic Journal
- Accession number :
- 25539929
- Full Text :
- https://doi.org/10.1152/japplphysiol.00101.2014