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Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2015 Mar; Vol. 30, pp. 147-158. Date of Electronic Publication: 2014 Dec 23. - Publication Year :
- 2015
-
Abstract
- A 14-bp insertion/deletion (indel) within the 3' untranslated region (3'UTR) that affects HLA-G expression has been associated with HIV-1 mother-to-child transmission (MTCT). However, other 3'UTR single nucleotide polymorphisms (SNPs) that influence HLA-G mRNA stability have been described but not analysed in the context of MTCT, and little is known about the role of HLA-G alleles. We examined HLA-G alleles and 3'UTR SNPs, including the 14-bp indel, in 216 mother-infant pairs from Johannesburg, South Africa. Mother-infant pairs were classified as HIV-1 non-transmitting (NT, n=144) or HIV-1 transmitting (TR, n=72) with either intrapartum (IP, n=29) or in utero (IU, n=19) infected infants. We found HLA-G allele, G(∗)01:01:02 (in strong linkage disequilibrium with the 14-bp insertion) and +3187G SNP were significantly over-represented in IU-TR mothers compared to NT mothers (P=0.036, OR=2.26; P=0.011, OR=2.96, respectively). These findings suggest that maternal HLA-G alleles and/or SNPs that might alter expression of HLA-G potentially influence IU HIV-1 MTCT.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- 3' Untranslated Regions genetics
Adult
Base Sequence
Black People statistics & numerical data
Case-Control Studies
Female
Gene Frequency
HIV-1
Haplotypes
Humans
INDEL Mutation genetics
Infant
Linkage Disequilibrium
Molecular Sequence Data
Mothers
Polymorphism, Single Nucleotide genetics
South Africa epidemiology
Young Adult
HIV Infections epidemiology
HIV Infections genetics
HIV Infections transmission
HLA-G Antigens genetics
Infectious Disease Transmission, Vertical
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 30
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 25541520
- Full Text :
- https://doi.org/10.1016/j.meegid.2014.12.021