Back to Search
Start Over
Baseline serum β-carotene concentration and mortality among long-term asbestos-exposed insulators.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2015 Mar; Vol. 24 (3), pp. 555-60. Date of Electronic Publication: 2014 Dec 26. - Publication Year :
- 2015
-
Abstract
- Background: Although interventional trials demonstrated that moderate-dose β-carotene supplementation increases lung cancer mortality in smokers and asbestos-exposed workers, differences in serum concentrations in absence of supplementation have not been studied in asbestos-exposed workers.<br />Methods: A mortality analysis was performed to assess the relationship of nonsupplemented serum β-carotene to all-cause and cancer mortalities using 1981 to 1983 serum β-carotene concentration measurements from 2,646 U.S. white male insulators (mean age, 57.7 years). Multivariable-adjusted Cox proportional hazard models that included terms for age, duration of asbestos exposure, smoking, season, and region were fitted to estimate mortality HRs and 95% confidence intervals (CI) according to serum β-carotene concentrations.<br />Results: Median follow-up was 12.8 years and 984 (33.8%) subjects died during the follow-up period, including 415 deaths from overall cancer and 219 deaths from lung cancer. The overall mortality HR for a serum β-carotene increase of 10 μg/dL was 0.97 (95% CI, 0.96-0.99). Compared with the lowest quartile, HRs were 0.90 (95% CI, 0.76-1.07) for the second (38-65 μg/dL), 0.80 (95% CI, 0.67-0.96) for the third (66-104 μg/dL), and 0.63 (95% CI, 0.51-0.77) for the highest serum β-carotene quartile (≥105 μg/dL). There was no association between serum β-carotene and overall cancer mortality (HR, 1.00; 95% CI, 0.97-1.02) or lung cancer mortality (HR, 0.99; 95% CI, 0.96-1.02).<br />Conclusions: Higher nonsupplemented serum β-carotene concentrations were negatively associated with all-cause mortality among asbestos-exposed individuals.<br />Impact: Serum β-carotene can be a marker of one or more determinants of reduced mortality in asbestos-exposed workers. Cancer Epidemiol Biomarkers Prev; 24(3); 555-60. ©2014 AACR.<br /> (©2014 American Association for Cancer Research.)
- Subjects :
- Canada epidemiology
Cohort Studies
Humans
Lung Neoplasms etiology
Lung Neoplasms mortality
Male
Middle Aged
Occupational Diseases etiology
Occupational Diseases mortality
Proportional Hazards Models
Risk Factors
United States epidemiology
Asbestos poisoning
Lung Neoplasms blood
Occupational Diseases blood
beta Carotene blood
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7755
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25542826
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-14-0952