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Differential Effect of Renal Cortical and Medullary Interstitial Fluid Calcium on Blood Pressure Regulation in Salt-Sensitive Hypertension.
- Source :
-
American journal of hypertension [Am J Hypertens] 2015 Aug; Vol. 28 (8), pp. 1049-55. Date of Electronic Publication: 2014 Dec 31. - Publication Year :
- 2015
-
Abstract
- Background: Hypercalciuria is a frequent characteristic of hypertension. In this report we extend our earlier studies investigating the role of renal interstitial fluid calcium (ISF(Ca))(2+) as a link between urinary calcium excretion and blood pressure in the Dahl salt-sensitive (DS) hypertensive model.<br />Methods: Dahl salt-sensitive and salt-resistant (DR) rats were placed on control (0.45%) and high (8%) salt diets to determine if changes in renal cortical and medullary ISF(Ca)(2+)correlated with changes in urinary calcium excretion and blood pressure.<br />Results: We observed that renal ISFCa(2+) was predicted by urinary calcium excretion (P < 0.05) in DS rats but not DR rats. Renal cortical ISF(Ca)(2+) was negatively associated with blood pressure (P < 0.03) while renal medullary ISF(Ca)(2+) was positively associated with blood pressure in DS rats (P < 0.04). In contrast, neither urinary calcium excretion nor renal ISF(Ca)(2+) was associated with blood pressure in the DR rats under the conditions of this study.<br />Conclusion: We interpret these findings to suggest that decreased renal cortical ISF(Ca)(2+) plays a role in the increase in blood pressure following a high salt diet in salt hypertension perhaps by mediating renal vasoconstriction; the role of medullary calcium remains to be fully understood. Further studies are needed to determine the mechanism of the altered renal ISF(Ca)(2+) and its role in blood pressure regulation.<br /> (© American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Animals
Blood Pressure drug effects
Calcium urine
Extracellular Fluid chemistry
Extracellular Fluid drug effects
Hypercalciuria urine
Hypertension urine
Kidney chemistry
Kidney drug effects
Kidney metabolism
Kidney Cortex chemistry
Kidney Cortex drug effects
Kidney Medulla chemistry
Kidney Medulla drug effects
Male
Microdialysis
Rats
Rats, Inbred Dahl
Sodium, Dietary pharmacology
Calcium metabolism
Extracellular Fluid metabolism
Hypercalciuria metabolism
Hypertension metabolism
Kidney Cortex metabolism
Kidney Medulla metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1941-7225
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 25552516
- Full Text :
- https://doi.org/10.1093/ajh/hpu255