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Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families.
- Source :
-
Circulation. Cardiovascular genetics [Circ Cardiovasc Genet] 2015 Feb; Vol. 8 (1), pp. 106-13. Date of Electronic Publication: 2014 Dec 31. - Publication Year :
- 2015
-
Abstract
- Background: Admixture mapping of lipids was followed-up by family-based association analysis to identify variants for cardiovascular disease in African Americans.<br />Methods and Results: The present study conducted admixture mapping analysis for total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. The analysis was performed in 1905 unrelated African American subjects from the National Heart, Lung and Blood Institute's Family Blood Pressure Program (FBPP). Regions showing admixture evidence were followed-up with family-based association analysis in 3556 African American subjects from the FBPP. The admixture mapping and family-based association analyses were adjusted for age, age(2), sex, body mass index, and genome-wide mean ancestry to minimize the confounding caused by population stratification. Regions that were suggestive of local ancestry association evidence were found on chromosomes 7 (low-density lipoprotein cholesterol), 8 (high-density lipoprotein cholesterol), 14 (triglycerides), and 19 (total cholesterol and triglycerides). In the fine-mapping analysis, 52 939 single-nucleotide polymorphisms (SNPs) were tested and 11 SNPs (8 independent SNPs) showed nominal significant association with high-density lipoprotein cholesterol (2 SNPs), low-density lipoprotein cholesterol (4 SNPs), and triglycerides (5 SNPs). The family data were used in the fine-mapping to identify SNPs that showed novel associations with lipids and regions, including genes with known associations for cardiovascular disease.<br />Conclusions: This study identified regions on chromosomes 7, 8, 14, and 19 and 11 SNPs from the fine-mapping analysis that were associated with high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides for further studies of cardiovascular disease in African Americans.<br /> (© 2014 American Heart Association, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Cardiovascular Diseases ethnology
Cardiovascular Diseases genetics
Family
Female
Humans
Male
Middle Aged
Black or African American genetics
Cholesterol, HDL genetics
Cholesterol, LDL genetics
Chromosome Mapping
Chromosomes, Human genetics
Polymorphism, Single Nucleotide
Triglycerides genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1942-3268
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Circulation. Cardiovascular genetics
- Publication Type :
- Academic Journal
- Accession number :
- 25552592
- Full Text :
- https://doi.org/10.1161/CIRCGENETICS.114.000481