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Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
- Source :
-
Science (New York, N.Y.) [Science] 2015 Jan 02; Vol. 347 (6217), pp. 83-6. - Publication Year :
- 2015
-
Abstract
- Lysosomes are crucial cellular organelles for human health that function in digestion and recycling of extracellular and intracellular macromolecules. We describe a signaling role for lysosomes that affects aging. In the worm Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclear translocalization of a lysosomal lipid chaperone LBP-8, which promoted longevity by activating the nuclear hormone receptors NHR-49 and NHR-80. We used high-throughput metabolomic analysis to identify several lipids in which abundance was increased in worms constitutively overexpressing LIPL-4. Among them, oleoylethanolamide directly bound to LBP-8 and NHR-80 proteins, activated transcription of target genes of NHR-49 and NHR-80, and promoted longevity in C. elegans. These findings reveal a lysosome-to-nucleus signaling pathway that promotes longevity and suggest a function of lysosomes as signaling organelles in metazoans.<br /> (Copyright © 2015, American Association for the Advancement of Science.)
- Subjects :
- Active Transport, Cell Nucleus
Animals
Caenorhabditis elegans genetics
Caenorhabditis elegans Proteins genetics
Cell Nucleus metabolism
Lipase metabolism
Lipid Metabolism
Longevity genetics
Molecular Chaperones genetics
Receptors, Cytoplasmic and Nuclear metabolism
Signal Transduction
Caenorhabditis elegans physiology
Caenorhabditis elegans Proteins metabolism
Longevity physiology
Lysosomes metabolism
Molecular Chaperones metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 347
- Issue :
- 6217
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 25554789
- Full Text :
- https://doi.org/10.1126/science.1258857