Back to Search
Start Over
Importance of tear film instability in dry eye disease in office workers using visual display terminals: the Osaka study.
- Source :
-
American journal of ophthalmology [Am J Ophthalmol] 2015 Apr; Vol. 159 (4), pp. 748-54. Date of Electronic Publication: 2014 Dec 30. - Publication Year :
- 2015
-
Abstract
- Purpose: To evaluate the relationship between subjective symptoms and clinical signs in dry eye disease (DED) in office workers using visual display terminals (VDTs).<br />Design: Cross-sectional study.<br />Methods: This study involved 672 Japanese young and middle-aged office workers who use VDTs. The subjects completed questionnaires designed to detect subjective symptoms and risk factors for DED. Dry eye tests, including tear film break-up time (TBUT), corneal-conjunctival staining with fluorescein and lissamine green, and the Schirmer test, were performed. Based on the Japanese diagnostic criteria for DED, the subjects were classified into 3 groups: definite DED, probable DED, and non-DED. Between each group, subjective symptoms and clinical signs were compared.<br />Results: Of the 672 subjects, 561 (374 male, 187 female) completed the questionnaire (response rate: 83.5%). Definite DED was diagnosed in 65 subjects (11.6%), probable DED in 303 subjects (54.0%), and non-DED in 193 subjects (34.4%). The mean subjective symptom score was significantly less in subjects with probable DED (2.05 ± 0.42) and non-DED (1.63 ± 0.38) than in those with definite DED (2.19 ± 0.40) (P < .05 and P < .01, respectively). In the subjects with probable DED, a subgroup with positive subjective symptoms and abnormal TBUT (≤5 seconds) was categorized as short TBUT-type DED, and it was found that they had a higher subjective symptom score (2.09 ± 0.40), equivalent to that of those with definite DED (P = .269).<br />Conclusions: Despite no or minor epithelial damage, the severity of subjective symptoms was greater in short TBUT-type DED, most likely attributable to tear film instability. Thus, it might prove important to evaluate TBUT to successfully treat those patients.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Conjunctiva
Cornea
Cross-Sectional Studies
Dry Eye Syndromes metabolism
Epithelial Cells
Female
Humans
Male
Middle Aged
Occupational Diseases metabolism
Office Automation
Prospective Studies
Risk Factors
Surveys and Questionnaires
Young Adult
Computer Terminals
Dry Eye Syndromes diagnosis
Occupational Diseases diagnosis
Tears metabolism
Workplace
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1891
- Volume :
- 159
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 25555800
- Full Text :
- https://doi.org/10.1016/j.ajo.2014.12.019