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Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain.
- Source :
-
Neuron [Neuron] 2015 Jan 21; Vol. 85 (2), pp. 377-89. Date of Electronic Publication: 2014 Dec 31. - Publication Year :
- 2015
-
Abstract
- Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain. Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors. Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Interestingly, chronic pain and anxiety both result in selective occlusion of pre-LTP. Significantly, microinjection of the HCN blocker ZD7288 into the ACC in vivo produces both anxiolytic and analgesic effects. Our results provide a mechanism by which two forms of LTP in the ACC may converge to mediate the interaction between anxiety and chronic pain.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Analgesics pharmacology
Animals
Anti-Anxiety Agents pharmacology
Anxiety physiopathology
Chronic Pain physiopathology
Gyrus Cinguli physiopathology
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels antagonists & inhibitors
Mice
Neurons physiology
Pyrimidines pharmacology
Synaptic Transmission physiology
Anxiety metabolism
Chronic Pain metabolism
Gyrus Cinguli metabolism
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels metabolism
Long-Term Potentiation physiology
Neurons metabolism
Receptors, Kainic Acid metabolism
Receptors, N-Methyl-D-Aspartate metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 85
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 25556835
- Full Text :
- https://doi.org/10.1016/j.neuron.2014.12.021