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Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2015 Jan 07; Vol. 21 (1), pp. 301-10. - Publication Year :
- 2015
-
Abstract
- Aim: To investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty acids.<br />Methods: A group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present study. Analysis of the fatty acid profiles was performed according to changes in liver steatosis (liver steatosis reduction by one or two degrees) after a six-month dietary intervention. The diet helped reduce body mass in obese and overweight patients, and stabilize both glycemia and dyslipidemia. Fatty acids were extracted according to the Folch method and analyzed by gas chromatography.<br />Results: This study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees. A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid (P < 0.055), docosapentaenoic acid-C 22:5 (P < 0.05) and docosahexaenoic acid (P < 0.05). A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1 (P < 0.05).<br />Conclusion: Liver steatosis reduction is associated with changes in fatty acid profiles, and these changes may reflect an alteration in fatty acid synthesis and metabolism. These findings may help better understand regression of nonalcoholic fatty liver disease.
- Subjects :
- Adult
Biomarkers blood
Blood Glucose metabolism
Dietary Fats blood
Docosahexaenoic Acids administration & dosage
Docosahexaenoic Acids blood
Eicosapentaenoic Acid administration & dosage
Eicosapentaenoic Acid blood
Fatty Acids blood
Fatty Acids, Monounsaturated administration & dosage
Fatty Acids, Monounsaturated blood
Fatty Acids, Unsaturated administration & dosage
Fatty Acids, Unsaturated blood
Female
Humans
Male
Middle Aged
Non-alcoholic Fatty Liver Disease blood
Non-alcoholic Fatty Liver Disease diagnosis
Non-alcoholic Fatty Liver Disease ethnology
Poland epidemiology
Prospective Studies
Remission Induction
Severity of Illness Index
Time Factors
Treatment Outcome
Weight Loss
White People
Young Adult
Dietary Fats administration & dosage
Fatty Acids administration & dosage
Non-alcoholic Fatty Liver Disease diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25574105
- Full Text :
- https://doi.org/10.3748/wjg.v21.i1.301