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Catheter ablation of atrial fibrillation in patients with rheumatoid arthritis.

Authors :
Wen SN
Liu N
Li SN
Salim M
Yan Q
Wu XY
Wang Y
Kang JP
Ning M
Wu JH
Ruan YF
Yu RH
Long DY
Tang RB
Sang CH
Jiang CX
Bai R
Hu R
Du X
Dong JZ
Liu XH
Ma CS
Source :
Journal of cardiology [J Cardiol] 2015 Oct; Vol. 66 (4), pp. 320-5. Date of Electronic Publication: 2015 Jan 09.
Publication Year :
2015

Abstract

Background: Rheumatoid arthritis (RA) is associated with an increased incidence of atrial fibrillation (AF). This study evaluated the safety and efficacy of catheter ablation (CA) in the treatment of AF in patients with RA, which has not been previously reported.<br />Methods: A total of 15 RA patients with AF who underwent CA were enrolled. For each RA patient, we selected 4 individuals (control group, 60 patients in total) who presented for AF ablation in the absence of structural heart or systemic disease and matched the RA patients with same gender, age (±2 years), type of AF, and procedure date.<br />Results: Patients with RA had a significantly higher C-reactive protein level (1.81 ± 2.35 mg/dl vs. 4.14 ± 2.30 mg/dl, p=0.0320), white blood cell count (5632 ± 1200 mm(3) vs. 6361 ± 1567 mm(3), p=0.0482), and neutrophil count (3308 ± 973 mm(3) vs. 3949 ± 1461 mm(3), p=0.0441). At 2-year follow-up, atrial tachyarrhythmia (ATa) recurrence rate in the RA group (33.3%, 5/15) was similar to that in the control group (31.7%, 19/60; p=0.579) after single procedure. In all the five patients from the RA group who developed recurrence, ATa relapsed within 90 days following index procedure (median recurrence time 18 days vs. 92 days in control group; p=0.0373). Multivariate Cox regression analysis showed that hypertension and left atrial diameter but not RA, C-reactive protein, white blood cell count, and neutrophil count were independent predictors of ATa recurrence.<br />Conclusions: Catheter ablation of AF can be safely performed in patients with RA, with a success rate comparable to that of patients without RA. RA patients tend to develop early ATa recurrence after AF ablation.<br /> (Copyright © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1876-4738
Volume :
66
Issue :
4
Database :
MEDLINE
Journal :
Journal of cardiology
Publication Type :
Academic Journal
Accession number :
25583089
Full Text :
https://doi.org/10.1016/j.jjcc.2014.12.003