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Kinetic resolution of racemic leukotriene A4 by mammalian cytosolic epoxide hydrolases.
- Source :
-
Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 1989 Oct; Vol. 38 (1), pp. 67-73. - Publication Year :
- 1989
-
Abstract
- Cytosols of rat and guinea pig liver and of human placenta were screened for their capacity to catalyze the conversion of racemic leukotriene A4 into 5S, 12R-dihydroxy-(Z,E,E,Z)-6,8,10,14-eicosatetraenoic acid (leukotriene B4). The epoxide hydrolase activities showed some specificity for the 5S,6S-oxido-(E,E,Z,Z)-7,9,11,14-eicosatetraenoic acid (LTA4) and produced mixtures of leukotriene B4 and its enantiomer containing up to 78-87% of leukotriene B4.
- Subjects :
- Animals
Chromatography, High Pressure Liquid
Cytosol enzymology
Female
Guinea Pigs
Kinetics
Leukotriene A4
Liver metabolism
Placenta metabolism
Pregnancy
Radioimmunoassay
Rats
Rats, Inbred Strains
Substrate Specificity
Epoxide Hydrolases metabolism
Leukotriene B4 metabolism
Leukotrienes metabolism
Liver enzymology
Placenta enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0952-3278
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Prostaglandins, leukotrienes, and essential fatty acids
- Publication Type :
- Academic Journal
- Accession number :
- 2558390
- Full Text :
- https://doi.org/10.1016/0952-3278(89)90150-6