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Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse: A Randomized Double-blind Controlled Multicentre Clinical Trial.
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2015 May; Vol. 95 (5), pp. 587-92. - Publication Year :
- 2015
-
Abstract
- Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD.
- Subjects :
- Administration, Cutaneous
Adolescent
Adult
Aged
Aged, 80 and over
Cross-Over Studies
Dermatitis, Atopic psychology
Double-Blind Method
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Proportional Hazards Models
Prospective Studies
Recurrence
Risk Assessment
Secondary Prevention methods
Severity of Illness Index
Sweden
Treatment Outcome
Young Adult
Dermatitis, Atopic diagnosis
Dermatitis, Atopic drug therapy
Dermatologic Agents administration & dosage
Emollients administration & dosage
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2057
- Volume :
- 95
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 25594845
- Full Text :
- https://doi.org/10.2340/00015555-2051