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The inverse autotransporter family: intimin, invasin and related proteins.
- Source :
-
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2015 Feb; Vol. 305 (2), pp. 276-82. Date of Electronic Publication: 2014 Dec 24. - Publication Year :
- 2015
-
Abstract
- Intimin and invasin are adhesins and central virulence factors of attaching and effacing bacteria, such as enterohaemorrhagic Escherichia coli, and enteropathogenic Yersiniae, respectively. These proteins are prototypes of a large family of adhesins distributed widely in Gram-negative bacteria. It is now evident that this protein family represents a previously unrecognized autotransporter secretion system, termed type Ve secretion. In contrast to classical autotransport, where the transmembrane β-barrel domain or translocation unit is C-terminal to the extracellular region or passenger domain, type Ve-secreted proteins have an inverted topology with the passenger domain C-terminal to the translocation unit; hence the term inverse autotransporter. This minireview covers the recent advances in elucidating the structure and biogenesis of inverse autotransporters.<br /> (Copyright © 2015 Elsevier GmbH. All rights reserved.)
- Subjects :
- Gram-Negative Bacteria chemistry
Gram-Negative Bacteria metabolism
Models, Molecular
Protein Conformation
Protein Multimerization
Protein Structure, Tertiary
Protein Transport
Virulence Factors chemistry
Virulence Factors metabolism
Adhesins, Bacterial chemistry
Adhesins, Bacterial metabolism
Escherichia coli Proteins chemistry
Escherichia coli Proteins metabolism
Membrane Transport Proteins chemistry
Membrane Transport Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0607
- Volume :
- 305
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of medical microbiology : IJMM
- Publication Type :
- Academic Journal
- Accession number :
- 25596886
- Full Text :
- https://doi.org/10.1016/j.ijmm.2014.12.011