Back to Search
Start Over
The recombinant maize ribosome-inactivating protein transiently reduces viral load in SHIV89.6 infected Chinese Rhesus Macaques.
- Source :
-
Toxins [Toxins (Basel)] 2015 Jan 19; Vol. 7 (1), pp. 156-69. Date of Electronic Publication: 2015 Jan 19. - Publication Year :
- 2015
-
Abstract
- Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation loop which is proteolytically removed for full catalytic activity. Here, we showed that the recombinant active maize RIP protected chimeric simian-human immunodeficiency virus (SHIV) 89.6-infected macaque peripheral blood mononuclear cells from lysis ex vivo and transiently reduced plasma viral load in SHIV89.6-infected rhesus macaque model. No evidence of immune dysregulation and other obvious side-effects was found in the treated macaques. Our work demonstrates the potential development of maize RIP as an anti-HIV agent without impeding systemic immune functions.
- Subjects :
- Animals
Leukocytes, Mononuclear drug effects
Leukocytes, Mononuclear virology
Macaca mulatta
Male
Recombinant Proteins therapeutic use
Simian Acquired Immunodeficiency Syndrome blood
Simian Acquired Immunodeficiency Syndrome virology
Anti-Retroviral Agents therapeutic use
Ribosome Inactivating Proteins therapeutic use
Simian Acquired Immunodeficiency Syndrome drug therapy
Simian Immunodeficiency Virus
Viral Load drug effects
Zea mays
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 25606813
- Full Text :
- https://doi.org/10.3390/toxins7010156