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Arthpyrones A-C, pyridone alkaloids from a sponge-derived fungus Arthrinium arundinis ZSDS1-F3.
- Source :
-
Organic letters [Org Lett] 2015 Feb 06; Vol. 17 (3), pp. 656-9. Date of Electronic Publication: 2015 Jan 21. - Publication Year :
- 2015
-
Abstract
- Three new 4-hydroxy-2-pyridone alkaloids, arthpyrones A-C (1-3), were isolated from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Their structures were elucidated on the basis of spectroscopic analysis, CD spectra, quantum chemical calculation, and X-ray single-crystal diffraction analysis. Compounds 1 and 2 possessed a 2-pyridone core featured with a decalin moiety linked via a carboxide bridge bearing a novel oxabicyclo[3.3.1]nonane ring system rarely discovered in nature. A possible biosynthetic pathway for them was proposed.
- Subjects :
- Alkaloids chemistry
Animals
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Crystallography, X-Ray
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
K562 Cells
MCF-7 Cells
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pyridines
Pyridones chemistry
Pyridones pharmacology
Alkaloids isolation & purification
Antineoplastic Agents isolation & purification
Ascomycota chemistry
Porifera microbiology
Pyridones isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 25606827
- Full Text :
- https://doi.org/10.1021/ol503646c