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Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers.
- Source :
-
Biomaterials [Biomaterials] 2015 Mar; Vol. 44, pp. 82-90. Date of Electronic Publication: 2015 Jan 12. - Publication Year :
- 2015
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Abstract
- Inorganic photosensitizer coupled Gd-based upconversion luminescent (UCL) nanocomposites have potential application for both magnetic resonance imaging (MRI) and photodynamic therapy (PDT) of cancers using the light stability and biocompatibility of TiO2 inorganic photosensitizer. However, TiO2 inorganic photosensitizer could only be excited by ultraviolet (UV) light, which was harmful and weakly penetrable in tissues. In this work, folic acid (FA)-targeted NaGdF4:Yb/Tm@SiO2@TiO2 nanocomposites (FA-Gd-Si-Ti NPs) were constructed and synthesized for both in vivo MRI and near infrared (NIR)-responsive inorganic PDT, in which TiO2 component could be excited by NIR light due to the UCL performance of NaGdF4:Yb/Tm component converting NIR to UV light. The results showed the as-prepared FA-Gd-Si-Ti NPs had good biocompatibility in vitro and in vivo. Moreover, MR study indicated that FA-Gd-Si-Ti NPs were good T1-weighted MRI contrast agents with high longitudinal relaxivity (r1) of 4.53 mm(-1) s(-1), also in vivo MRI of nude mice showed "bright" signal in MCF-7 tumor. Under the irradiation of 980 nm laser at the power density of 0.6 W/cm(2) for 20 min, the viability of HeLa and MCF-7 cells incubated with FA-Gd-Si-Ti NPs could decrease from about 90 % to 35 % and 31%, respectively. Furthermore, in vivo PDT of MCF-7 tumor-bearing nude mice model showed that the inhibition ratio of tumors injected with FA-Gd-Si-Ti NPs reached up to 88.6% after 2-week treatment, compared with that of nude mice in control group. Based on the deep penetration of NIR light and the good biocompatibility of TiO2 inorganic photosensitizer, the as-prepared FA-Gd-Si-Ti NPs could have potential applications in both MRI and NIR-responsive PDT of cancers in deep tissues.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Cell Death drug effects
Cell Survival drug effects
Female
Folic Acid pharmacology
HeLa Cells
Humans
MCF-7 Cells
Mice
Mice, Nude
Nanocomposites ultrastructure
Neoplasms pathology
Photosensitizing Agents pharmacology
Scattering, Radiation
Silicon Dioxide
Static Electricity
Titanium
X-Ray Diffraction
Gadolinium pharmacology
Luminescence
Magnetic Resonance Imaging
Nanocomposites chemistry
Neoplasms drug therapy
Photochemotherapy
Photosensitizing Agents therapeutic use
Spectroscopy, Near-Infrared
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5905
- Volume :
- 44
- Database :
- MEDLINE
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 25617128
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2014.12.040