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Kindlin-2: a novel prognostic biomarker for patients with hepatocellular carcinoma.
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2015 Mar; Vol. 211 (3), pp. 198-202. Date of Electronic Publication: 2014 Oct 02. - Publication Year :
- 2015
-
Abstract
- The association of aberrant expression of Kindlin-2 with tumor progression has been reported in recent years. The purpose of this study was to investigate the expression of Kindlin-2 in hepatocellular carcinoma (HCC), and to evaluate its clinical and prognostic significance. The mRNA and protein levels of Kindlin-2 in HCC and adjacent non-cancerous tissues were examined by real-time PCR and western blotting. The relationships between Kindlin-2 expression, clinicopathological features and postoperative survival of HCC patients were also evaluated. Kindlin-2 expression was higher in HCC tissues as compared to adjacent non-cancerous tissues at both mRNA and protein levels (P<0.05, respectively). Positive expression of Kindlin-2 was significantly correlated with larger tumor size (P=0.034), capsular invasion (P=0.009), microvascular invasion (P=0.028) and poor prognosis of HCC patients (P<0.001). Moreover, multivariate survival analysis identified Kindlin-2 as an independent prognostic factor for overall and disease-free survival of HCC patients (P=0.018 and 0.001, respectively). Taken together, our findings suggested that Kindlin-2 was highly expressed in HCC tissues and was closely related to clinical progression. Therefore, Kindlin-2 protein could be a potential biomarker for predicting poor prognosis of HCC patients after surgery.<br /> (Copyright © 2014 Elsevier GmbH. All rights reserved.)
- Subjects :
- Carcinoma, Hepatocellular metabolism
Carcinoma, Hepatocellular mortality
Disease Progression
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Liver Neoplasms metabolism
Liver Neoplasms mortality
Male
Middle Aged
Prognosis
Survival Rate
Biomarkers, Tumor metabolism
Carcinoma, Hepatocellular pathology
Liver Neoplasms pathology
Membrane Proteins metabolism
Neoplasm Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 211
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 25618552
- Full Text :
- https://doi.org/10.1016/j.prp.2014.09.011